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T36621
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Prostaglandin F2β
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Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α. It is much less active than PGF2α in antifertility and bronchoconstrictor activities. PGF2β exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α. |
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T37165
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8-iso Prostaglandin F2β
8-iso Prostaglandin F2β
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8-iso Prostaglandin F2β 可用于生命科学领域的相关研究。其产品编号为 T37165，CAS号为 177020-26-7。 |
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T36167
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8-iso-15-keto Prostaglandin F2β
8-iso-15-keto Prostaglandin F2β
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8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8... |
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T38198
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Prostaglandin F2α methyl ester
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Prostaglandin F2α methyl ester 是一种具有高脂溶性的 PGF2α 类似物，用用于维持低眼压。 |
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T36455
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11β-Prostaglandin F2α
11β-Prostaglandin F2α
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11β-Prostaglandin F2α 是一种由 AKR1C3 催化的生物活性代谢物，可刺激前列腺素 F 受体并诱导乳腺癌中的 slug 表达。11β-Prostaglandin F2α 也是存在于尿液中的内源代谢物。 |
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T38195
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Prostaglandin F2α Ethanolamide
Prostaglandin F2α Ethanolamide
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Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues. AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs. PGF2α-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2α-EA is a potent dilator (... |
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T38197
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Prostaglandin F2α Alcohol
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Prostaglandin F2α Alcohol 是 PGF2α（T15133）类似物。Prostaglandin F2α Alcohol 是一种具有口服活性的前列腺素 F 受体 (FP receptor) 激动剂。 |
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T38196
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Prostaglandin F2α isopropyl ester
Prostaglandin F2α isopropyl ester
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PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 μg dose reduces intraocular pressure by 68% after the fourth day of treatment. |
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T35992
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ent-Prostaglandin F2α
ent-Prostaglandin F2α
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ent-Prostaglandin F2α 是 PGF2α 的对映体，在尿液中可被发现。 |
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T37946
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17-trifluoromethylphenyl trinor Prostaglandin F2α
17-trifluoromethylphenyl trinor Prostaglandin F2α
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A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trin... |
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T36146
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13,14-dihydro Prostaglandin F2α
13,14-dihydro Prostaglandin F2α,13,14-dihydro PGF2α
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13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 µg/100 g.[1] |
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T36617
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ent-8-iso Prostaglandin F2α
ent-8-iso Prostaglandin F2α
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ent-8-iso Prostaglandin F2α 是猪视网膜和脑微血管的强效血管收缩剂，EC50 值分别为 30.6 和 53.5 nM。 |
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T37327
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Prostaglandin F2α 1,15-lactone
Prostaglandin F2α 1,15-lactone
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PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, whereas PGF2α is ineffective. |
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T37995
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16-phenoxy tetranor Prostaglandin F2α
16-phenoxy tetranor Prostaglandin F2α
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16-phenoxy PGF2α is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. |
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T37993
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16,16-dimethyl Prostaglandin F2α
16,16-dimethyl Prostaglandin F2α
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16,16-dimethyl Prostaglandin F2α 可用于生命科学领域的相关研究。其产品编号为 T37993，CAS号为 39746-23-1。 |
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T37840
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20-hydroxy Prostaglandin F2α
20-hydroxy Prostaglandin F2α
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20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway. |
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T37275
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2,3-dinor-11β-Prostaglandin F2α
2,3-dinor-11β-Prostaglandin F2α
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2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively. 2,3-dinor-11β-PGF2α has also been recovered from the urine of mastocytosis patients, where it is excreted in large amounts. In human asthmatic patients, 2,3-dinor-11β-PGF2α represents about 40% (as determined by GC/MS) of the immunoreactive 11β-PGF2α wh... |
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T37991
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15-keto Prostaglandin F2α
15-keto Prostaglandin F2α,15-keto PGF2α
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Endogenous Metabolite;
Prostaglandin Receptor |
GPCR/G Protein;
Immunology/Inflammation;
Metabolism |
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15-keto Prostaglandin F2α 是 Prostaglandin F2α 的代谢物，可降低兔眼压。 |
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T37940
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17-phenyl trinor Prostaglandin F2α cyclopropyl amide
17-phenyl trinor Prostaglandin F2α cyclopropyl amide
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17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide. There are no published reports on the biological activity of 17-phenyl trinor PGF2α cyclopropyl amide. |
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T35990
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ent-8-iso-15(S)-Prostaglandin F2α
ent-8-iso-15(S)-Prostaglandin F2α
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Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2α (ent-8-iso-15(S)-PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively. This isoprostane is about ten-fold more potent than 8-iso-PGF2α in a whole blood pla... |
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T36166
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8-iso-15-keto Prostaglandin F2α
8-iso-15-keto Prostaglandin F2α
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8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the in... |
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T37941
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17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
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Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF2α ethyl amide. 17-phenyl trinor PGF2α ethyl amide is used to reduce intraocular pressure related to glaucoma. 17-phenyl trinor PGF2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF... |
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T37935
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16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide
16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide
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The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor. 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide (16-phenoxy tetranor PGF2α cyclopropyl methyl amide) is an analog of PGF2α containing a 16-phenoxy group on the lower (ω) side chain and a cyclopropyl methyl amide at the C-1 position. There are no published reports on the biological... |
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T37942
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17-phenyl trinor Prostaglandin F2α dimethyl amide
17-phenyl trinor Prostaglandin F2α dimethyl amide
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17-phenyl trinor Prostaglandin F2αdimethyl amide is an isomer of 17-phenyl trinor prostaglandin F2αethyl amide .
N/A |
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T37947
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17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
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Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α methyl ester is a lipophil... |
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T37938
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17-phenoxy trinor Prostaglandin F2α ethyl amide
17-phenoxy trinor Prostaglandin F2α ethyl amide
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Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. Both 17-phenyl trinor PGF2α and 16-phenoxy tetranor PGF2α are metabolically stable analogs of PGF2α and potent agonists for the FP receptor. 17-phenoxy trinor PGF2α ethyl amide is a lipophilic analog of 17-phenoxy trinor PGF2α . Ethyl amides of PGs serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid. |
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T37943
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17-phenyl trinor Prostaglandin F2α isopropyl ester
17-phenyl trinor Prostaglandin F2α isopropyl ester
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17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP r... |
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T37934
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15-keto-17-phenyl trinor Prostaglandin F2α
15-keto-17-phenyl trinor Prostaglandin F2α
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Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compo... |
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T37944
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17-phenyl trinor Prostaglandin F2α methyl amide
17-phenyl trinor Prostaglandin F2α methyl amide
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17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α. The ethyl amide of 17-phenyl trinor PGF2α bimatoprost has been approved for use as an ocular hypotensive drug. 17-phenyl trinor PGF2α methyl amide is an analog of bimatoprost. Its biological and toxicological properties have not been evaluated. |
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T37937
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16-phenoxy tetranor Prostaglandin F2α methyl ester
16-phenoxy tetranor Prostaglandin F2α methyl ester
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic a... |
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T37936
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16-phenoxy tetranor Prostaglandin F2α isopropyl ester
16-phenoxy tetranor Prostaglandin F2α isopropyl ester
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α isopropyl ester (16-phenoxy tetranor PGF2α isopropyl ester) is a lipophilic analog of 16-phenoxy tetranor PGF2α. Isopropyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid. |
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T37930
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15(R)-17-phenyl trinor Prostaglandin F2α
15(R)-17-phenyl trinor Prostaglandin F2α
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17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-ph... |
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T37777
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17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
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Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α (17-trifluoromethylphenyl trinor PGF2α) is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoro... |
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T35944
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15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
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Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacologi... |
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T36165
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8-iso-13,14-dihydro-15-keto Prostaglandin F2α
8-iso-13,14-dihydro-15-keto Prostaglandin F2α
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8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into ra... |
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T36155
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15(S)-15-methyl Prostaglandin F2α isopropyl ester
15(S)-15-methyl Prostaglandin F2α isopropyl ester
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15(S)-15-methyl Prostaglandin F2α (15(S)-15-methyl PGF2α) has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor. 15(S)-15-methyl PGF2α isopropyl ester is a lipophilic analog of 15(S)-15-methyl PGF2α methyl ester, which may be hydrolyzed in vivo to the fully active free acid. |
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T37948
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17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
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A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As a... |
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T36156
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15(S)-15-methyl Prostaglandin F2α methyl ester
15(S)-15-methyl Prostaglandin F2α methyl ester
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15(S)-15-methyl Prostaglandin F2α methyl ester 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T36156，CAS号为 35700-21-1。 |
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